High frequency stimulation of the posterior hypothalamic nucleus restores movement and reinstates hippocampal-striatal theta coherence following haloperidol-induced catalepsy
Identifieur interne : 002398 ( Main/Exploration ); précédent : 002397; suivant : 002399High frequency stimulation of the posterior hypothalamic nucleus restores movement and reinstates hippocampal-striatal theta coherence following haloperidol-induced catalepsy
Auteurs : Jesse Jackson [Canada] ; Calvin K. Young [Canada] ; BIN HU [Canada] ; Brian H. Bland [Canada]Source :
- Experimental neurology : (Print) [ 0014-4886 ] ; 2008.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Deep brain stimulation (DBS) of the subthalamic nucleus has been used extensively in the treatment of Parkinson's disease. However, the efficacy of such treatments on bradykinesia/akinesia remains low. DBS of the posterior hypothalamic nucleus (PH) elicits spontaneous, non-stereotypical motor behaviours. We tested the hypothesis that PH stimulation could restore movement in animals made cataleptic by the D2 receptor antagonist haloperidol. We further hypothesized that hippocampal-striatal neural synchrony may be important in the organization of motor behaviours. Animals chronically implanted with hippocampal and striatal recording electrodes and PH stimulating electrode were tested in open field, catalepsy and active avoidance paradigms. The degree of hippocampal-striatal theta (5-10 Hz) field coherence was assessed during baseline avoidance testing and following the administration of haloperidol. Haloperidol abolished movement in open field and active avoidance tasks and increased the latency to respond in the catalepsy test. Stimulation of the PH under haloperidol reversed catalepsy. Hippocampal-striatal theta coherence was high throughout the active avoidance task in control experiments but was greatly reduced under haloperidol. PH stimulation was able to reinstate the hippocampal-striatal theta coherence while restoring task-related behaviours. These results support the hypothesis that DBS of the PH could restore motor behaviours in rats made cataleptic with haloperidol, thus providing strong support for the PH as a promising candidate for DBS in the treatment of Parkinson's disease. Furthermore, the results support the view that hippocampal-striatal theta coherence may be important for the planning and execution of goal-oriented behaviors.
Affiliations:
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Young</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Psychology, Behavioral Neuroscience Research Group, The University of Calgary</s1><s2>Calgary, Alberta, T2N 1N4</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Calgary</settlement><region type="state">Alberta</region></placeName><orgName type="university">Université de Calgary</orgName></affiliation></author><author><name sortKey="Bin Hu" sort="Bin Hu" uniqKey="Bin Hu" last="Bin Hu">BIN HU</name><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Hotchkiss Brain Institute, Faculty of Medicine, The University of Calgary</s1><s2>Alberta, T2N 1N4</s2><s3>CAN</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Calgary</settlement><region type="state">Alberta</region></placeName><orgName type="university">Université de Calgary</orgName></affiliation></author><author><name sortKey="Bland, Brian H" sort="Bland, Brian H" uniqKey="Bland B" first="Brian H." last="Bland">Brian H. Bland</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Department of Psychology, Behavioral Neuroscience Research Group, The University of Calgary</s1><s2>Calgary, Alberta, T2N 1N4</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Calgary</settlement><region type="state">Alberta</region></placeName><orgName type="university">Université de Calgary</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Hotchkiss Brain Institute, Faculty of Medicine, The University of Calgary</s1><s2>Alberta, T2N 1N4</s2><s3>CAN</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Calgary</settlement><region type="state">Alberta</region></placeName><orgName type="university">Université de Calgary</orgName></affiliation></author></analytic><series><title level="j" type="main">Experimental neurology : (Print)</title><title level="j" type="abbreviated">Exp. neurol. : (Print)</title><idno type="ISSN">0014-4886</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Experimental neurology : (Print)</title><title level="j" type="abbreviated">Exp. neurol. : (Print)</title><idno type="ISSN">0014-4886</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Catalepsy</term><term>Coherence</term><term>Deep brain stimulation</term><term>Dopamine</term><term>Haloperidol</term><term>High frequency</term><term>Hippocampus</term><term>Nervous system diseases</term><term>Parkinson disease</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Catalepsie</term><term>Maladie de Parkinson</term><term>Pathologie du système nerveux</term><term>Haute fréquence</term><term>Hippocampe</term><term>Cohérence</term><term>Halopéridol</term><term>Dopamine</term><term>Stimulation cérébrale profonde</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Deep brain stimulation (DBS) of the subthalamic nucleus has been used extensively in the treatment of Parkinson's disease. However, the efficacy of such treatments on bradykinesia/akinesia remains low. DBS of the posterior hypothalamic nucleus (PH) elicits spontaneous, non-stereotypical motor behaviours. We tested the hypothesis that PH stimulation could restore movement in animals made cataleptic by the D<sub>2</sub> receptor antagonist haloperidol. We further hypothesized that hippocampal-striatal neural synchrony may be important in the organization of motor behaviours. Animals chronically implanted with hippocampal and striatal recording electrodes and PH stimulating electrode were tested in open field, catalepsy and active avoidance paradigms. The degree of hippocampal-striatal theta (5-10 Hz) field coherence was assessed during baseline avoidance testing and following the administration of haloperidol. Haloperidol abolished movement in open field and active avoidance tasks and increased the latency to respond in the catalepsy test. Stimulation of the PH under haloperidol reversed catalepsy. Hippocampal-striatal theta coherence was high throughout the active avoidance task in control experiments but was greatly reduced under haloperidol. PH stimulation was able to reinstate the hippocampal-striatal theta coherence while restoring task-related behaviours. These results support the hypothesis that DBS of the PH could restore motor behaviours in rats made cataleptic with haloperidol, thus providing strong support for the PH as a promising candidate for DBS in the treatment of Parkinson's disease. Furthermore, the results support the view that hippocampal-striatal theta coherence may be important for the planning and execution of goal-oriented behaviors.</div></front></TEI><affiliations><list><country><li>Canada</li></country><region><li>Alberta</li></region><settlement><li>Calgary</li></settlement><orgName><li>Université de Calgary</li></orgName></list><tree><country name="Canada"><region name="Alberta"><name sortKey="Jackson, Jesse" sort="Jackson, Jesse" uniqKey="Jackson J" first="Jesse" last="Jackson">Jesse Jackson</name></region><name sortKey="Bin Hu" sort="Bin Hu" uniqKey="Bin Hu" last="Bin Hu">BIN HU</name><name sortKey="Bland, Brian H" sort="Bland, Brian H" uniqKey="Bland B" first="Brian H." last="Bland">Brian H. Bland</name><name sortKey="Bland, Brian H" sort="Bland, Brian H" uniqKey="Bland B" first="Brian H." last="Bland">Brian H. Bland</name><name sortKey="Young, Calvin K" sort="Young, Calvin K" uniqKey="Young C" first="Calvin K." last="Young">Calvin K. 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